The network has ordered 10 half-hour episodes of the untitled series from "American Idol" producer FremantleMedia North America. The show will follow the actress at home with her teenage children, at work and as she launches a new weight-loss program.
The 58-year-old Alley, who starred in the sitcoms "Veronica's Closet" and "Cheers," appeared in the 2005 Showtime comedy series "Fat Actress." She played a version of herself coping with Hollywood's fixation on thinness.
She has also been a spokeswoman for the Jenny Craig diet program.
The A&E series is to air next year.