It happened in the 1900 block of Route 40 shortly before 1:30 p.m.
The ladder truck from the Christiana Fire Department was responding to a fire in the Fox Run Apartments when it collided with another vehicle.
Two occupants of the other vehicle were briefly trapped. They were both taken to Christiana Hospital with non-life threatening injuries.
No firefighters were hurt.
All Westbound lanes of Route 40 were closed temporarily with traffic getting by on the shoulder.