The award will be presented to Scorsese at the 67th annual Globes on Jan. 17.
Scorsese turns 67 next week and is an Academy Award winner for directing on "The Departed" and a two-time Golden Globe winner for that film and "Gangs of New York." He also was nominated for Oscars and Globes for such films as "Raging Bull," "Goodfellas" and "The Aviator."
Past winners of the DeMille award include last year's recipient, Steven Spielberg, along with Warren Beatty, Anthony Hopkins and Michael Douglas.
Nominations come out Dec. 15 for the Globes, Hollywood's second-biggest film honors after the Oscars.