The crash occurred around 11:30 in the southbound lanes of the Boulevard just south of Tyson Street.
Two vehicles collided, the impact of the crash sent one of the vehicles into a pole. The other vehicle struck a tree.
All three victims were taken to Aria Hospital-Torresdale Division with multiple injuries.
No word yet on what caused the accident.
Traffic was diverted from the scene for an hour while police conducted their investigation.