Lead producer Michael Cohl announced Tuesday that the much-anticipated show will begin preview performances on November 14, with opening night set for Dec. 21.
Its home will be the former Hilton Theatre, now renamed the Foxwoods Theatre.
Based on the Marvel comic book hero, "Spider-Man" features music and lyrics by Bono and The Edge, with a book by its director, Julie Taymor, and Glen Berger.
Destined to be one of the most expensive musicals in Broadway history, it has been in the works for six years and faced financial hurdles.
At one point, it was scheduled to begin performances this past winter.