It happened just after 3:30 p.m. Sunday along the 300 block of Pear Street.
Reading police say 64-year-old Chukwudubem Okafor and his 37-year-old wife Cheryl were found shot to death inside the residence.
Police believe Mr. Okafor shot his wife, then turned the gun on himself.
Police say several Okafor's relatives were in the house at the time of the shooting and are being questioned.