The accident occurred just before 11:00 a.m.in Mount Laurel, just north of Route 73.
Police say a man was running out from the wood and ran onto the highway.
He was then struck by the tractor trailer.
The pedestrian was flown to Cooper Hospital in serious condition.
It was not clear why the male was running out of the woods.
The truck was also rear ended by another vehicle. There did not appear to any injuries from that accident.