It happened around 10:25 Monday night on the 2400 block of 76th Avenue near Ogontz, in the city's West Oak Lane section.
A 21-year-old man was shot in the shoulder and leg, and another person was shot in the leg. Both victims were taken to Albert Einstein Medical Center for treatment.
Their conditions have not been released.
So far, no word on a motive or suspect in the shooting.