It happened around 6:00 p.m. in the 1900 block of North 5th Street.
Police say the driver of a car lost control of his vehicle and hit a tree.
The men in their car, all in their 20's, were taken to Temple University Hospital.
A 24-year-old male, who was the front passenger, is listed in critical condition.
Three others are listed in stable condition.
There is no word yet on how this crash happened.
