The Republican candidate's past statements were fodder for the opening sketch on Saturday night's broadcast on NBC.
The sketch involved actors portraying the tea party darling O'Donnell and two Republican officials concerned about her past statements, including speaking out against masturbation.
The actress playing O'Donnell says she is no longer against masturbation and, in fact, masturbates constantly. She also says she once ran a dog fighting operation and burned down somebody's house.
The sketch ends with the actress donning a witch hat and flying away on a broom, a reference to O'Donnell's claim years ago that she dabbled in witchcraft in high school.