Gunfire erupted just after 2:00 a.m. at the intersection of 2nd Street and Indiana Avenue.
A 22-year-old man was shot once in the neck. He was rushed to Episcopal Hospital and later transferred to Temple University Hospital where is currently listed in critical condition.
Another victim, also a 22-year-old male, was shot once in the right foot and is in stable condition at Temple University Hospital.
Police say no arrests have been made.