Horse racing's biggest star closed from dead last on Saturday, only for Blame to hold off the 6-year-old mare and win the $5 million Breeders' Cup Classic under the lights Churchill Downs.
Blame went to the front in the middle of the stretch, then fought off another spectacular bid from the unbeaten Zenyatta to win by a head.
Zenyatta entered the race hoping to improve to 20-0 on her career. She loped behind the field for the first mile of the race before closing in a hurry.
Blame answered the challenge.
The 4-year-old horse covered the 1 1/4-mile distance in 2:02.28 as a 5-to-1 shot. Fly Down held on for third, while Preakness champion Lookin At Lucky finished fourth.