Paisley has been nominated for the award every year since 2005. Though he's won 13 CMAs since first being nominated in 2000, he's never won the biggest award.
Paisley is a favorite to win. But he faces tough competition from Miranda Lambert, Lady Antebellum, the Zac Brown Band and former winner Keith Urban.
Paisley is hosting the 44th Country Music Association Awards with Carrie Underwood. The show will air live on ABC from Nashville.