The Hollywood Reporter announced Tuesday that the 65-year-old Oscar winner will receive the Sherry Lansing Leadership Award at a ceremony next month.
Halle Berry will present the award to Mirren at the Women in Entertainment breakfast on Dec. 7, where Katie Couric is set to give the keynote address.
The Sherry Lansing Leadership Award is presented annually to a woman who has built a unique entertainment career and made significant contributions to society.
Previous recipients include Berry, Barbara Walters, Meryl Streep, Jodie Foster and Glenn Close.
A four-time Oscar nominee, Mirren won an Academy Award and a Golden Globe for her performance in 2006's "The Queen."