Philadelphia is 3-0 against the Islanders this season and has won 21 of the past 23 meetings between the Atlantic Division rivals. New York had taken a 2-1 lead in the third period on goals by P.A. Parenteau and Frans Nielsen in a span of 36 seconds.
Matt Carle and Andreas Nodl also scored for Philadelphia, and Sergei Bobrovsky stopped 28 shots for the win.
The Islanders lost for the 17th time in 18 games (1-14-3). Dwayne Roloson made 24 saves.