Spencer Hawes had 16 points and 12 rebounds, and Elton Brand added 15 points for the Sixers, who have won three straight and seven of nine.
Blake Griffin had 20 points and 18 rebounds, matching his career high, to pace the Clippers (5-21), who have dropped all 11 of their road games this season. Counting last season, Los Angeles has lost 15 straight on the road and hasn't won away from home since defeating Houston on March 25 last season.
For Griffin, it was his 13th straight game with a double-double. Clippers guard Baron Davis broke out of his recent funk, scoring a season-high 18 points after averaging 4.3 points in his previous four games. Davis entered averaging 7.4 points per game this season, his lowest output since scoring 5.9 per game during his rookie season in 1999. Davis had just two points after halftime.
Eric Gordon had 16 points and DeAndre Jordan 15 for the Clippers.
Los Angeles led 56-53 at halftime before a woeful third quarter. Iguodala had eight points, making all three of his field goal attempts, as the Sixers outscored the Clippers 34-18 in the period. The Sixers went 11 for 23 (47.8 percent) from the field, including 3 for 6 from 3-point range, in the quarter. The Clippers, meanwhile, missed 13 of 19 shots.
The period didn't start badly for Los Angeles, which upped its advantage to 66-62 just 3:54 into the quarter, but it was all Philadelphia after that. Iguoadala's three-point play with 1.2 seconds left gave the Sixers an 87-74 lead entering the fourth after they outscored Los Angeles 25-8 over the last 8:06 of the third.
The Clippers never got closer than 10 points in the final quarter.
Philadelphia matched its season low with five turnovers.
NOTES: Clippers forward Rasual Butler, a La Salle University product, played in his 174th straight game. He was scoreless in 17 minutes. ... Hawes must enjoy playing against the Clippers. He set his career high of 30 points last season on Jan. 1 at Los Angeles. ... Clippers guard Randy Foye, a Villanova product, had two points in 5 minutes in his first game back after missing the previous eight with a strained left hamstring.