The announcement by the nation's third-largest airline came on Tuesday after a judge in Chicago said he would not block American from pulling its flight information off of Orbitz.
The airline said its tickets sold previously on Orbitz are still valid.
And American Airlines tickets can still be bought at the airline's own website as well as other travel websites.
American is a unit of AMR Corp.
Orbitz is run by Orbitz Worldwide Inc.
American also said it would not sell tickets through the Orbitz for Business website.