Federal Aviation Administration spokesman Jim Peters said the collision occurred at about 2:30 p.m. Friday a half mile north of the Shenandoah Valley Regional Airport in Weyers Cave.
The two people killed were aboard the Cessna 172 plane. The names of the victims weren't immediately released. Peters said the helicopter was damaged but landed safely with two crew members and a patient aboard.
He says the occupants of the helicopter walked away, and he was not aware of any injuries on the ground.
Peters says the National Transportation Safety Board is investigating.