The crash happened around 4:30 a.m. Thursday on the southbound lanes of Route 295 near Exit 16B in East Greenwich Township.
A tanker tractor trailer hauling liquid asphalt overturned in the crash, falling on top of a SUV - crushing the vehicle.
One person involved in the crash was trapped inside their vehicle and needed to be extricated.
There is no word on the conditions of those injured at this time.
Drivers should expect delays as crews remain on the scene.