Police say a motorcycle and a minivan collided shortly before 5:30 p.m. on the 300 block of West Main Street in Birdsboro, Pa.
Authorities say the two fatalities were from the motorcycle.
Police say due to the impact of the crash, their bodies were found inside the van.
Several people inside the van suffered multiple injuries and were taken to a local hospital.
The specifics of their injuries have not been disclosed.
The victims' names have not been released.
WFMZ contributed to this report.