On Wednesday afternoon, Vick said there is a "100% chance I'll start."
Vick participated in a walkthrough on Wednesday morning, and is expected to fully practice with the team during the afternoon session.
Vick suffered a hand contusion in the Eagles' 29-16 loss to the New York Giants on Sunday. But Philadelphia coach Andy Reid says the swelling is down.
The Eagles play at home vs. the San Francisco 49ers.
Though still early, Vick and the Eagles (1-2) find themselves in last place in the NFC East, as the Giants, Redskins and Cowboys are all 2-1.