It all started when one vehicle slammed into another one at about 2:15 on Thursday morning, at 51st and Locust streets.
The impact flipped one of the cars onto the roof of a third car.
Emergency crews had to pry open the vehicles to free the trapped drivers and passengers.
The woman who died was a passenger in the striking vehicle.
She was pronounced dead at the scene.
The survivors have all suffered head, neck and back injuries.
The hospitals where they were transported have not released their exact conditions.
Police are trying to determine what caused the accident.