Describing Aniston Monday night at Elle magazine's Women in Hollywood event, Witherspoon said, "you just want to get your nails done with her and you want to make out with her at the same time."
"At least I do," the "Walk the Line" star playfully confessed. "And that's what we do sometimes on Saturdays!"
Aniston was honored at the 18th annual ceremony at the Four Seasons Hotel in Los Angeles, along with Barbra Streisand, Viola Davis, Michelle Pfeiffer, Elizabeth Olsen, Evan Rachel Wood, Naomi Watts, Freida Pinto and DreamWorks chief Stacey Snider.
Witherspoon joked that she gets to enjoy manicure-and-makeout Saturdays with Aniston "because she's my friend, not yours."