The accident occurred just after 11:30 a.m. between Gulph Mills Road and Route 202.
The accident involved two vehicles and one tractor-trailer, but it remains unclear what led to the crash.
There is no immediate word on who was killed in this crash.
A number a injuries were reported. Chopper 6 HD was overhead as two people were placed in waiting ambulances.
The scene is just a few hundreds yards from a new westbound off-ramp PennDOT opened about an hour before the wreck.
That ramp sends traffic onto South Gulph Road and South Henderson Road.
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