The layoff notices going out Friday are the result of $15 million in cuts announced by the district in December as it tries to cut a $629 million budget deficit.
Forty-seven of the workers laid off are school nurses. The remainder are also nonteaching positions.
District spokesman Fernando Gallard says the layoffs are necessary to help stabilize the district's financial situation.
Philadelphia Federation of Teachers President Jerry Jordan says the union will try to fight the layoffs.