It happened around 3:50 Sunday morning on the 100 block of East 13th Street.
Police received a report of shots fired and arrived to find an unidentified male shot multiple times.
The victim was pronounced dead at the scene. No word on his identity.
Authorities say they have no suspects at this time.
Anyone with information is asked to call Wilmington Police at 302-576-3632. To submit a tip anonymously call 1-800-TIP-333 3 or visit www.tipsubmit.com.