It happened around 1:00 Saturday morning on I-95 near Churchman's Marsh.
Police tell Action News that the taxicab was travelling south on I-95 when it struck the rear of a dump truck.
The crash left the driver and a passenger stuck inside.
Rescue crews worked to free both victims and they were taken to Christiana Hospital.
The driver - a man in his 60s - was pronounced dead upon arrival. The passenger is listed in serious condition with multiple injuries.
Three lanes of I-95 were closed as Delaware State Police investigated but has since reopened.
