The crash happened at 10:53 p.m. in the southbound lanes of the highway near Route 896.
Police say Marva G. Wright, 33, of Baltimore, was riding her 2003 Suzuki motorcycle at a high rate of speed when she lost control.
Investigators say Wright tried to brake, but the sudden stop forced the rear of the motorcycle up, ejecting her from the bike.
She landed on the highway where she was hit by a Honda Civic. Police say the driver was unable to avoid her.
The motorcycle went on to hit a 2010 Toyota Prius.
Wright was pronounced dead at the scene.
The drivers of the other two cars involved were not hurt.