It happened at 3:45 p.m. in the southbound lanes approaching the White Horse Pike (Route 30) in Lawnside.
Video from Chopper 6 HD over the scene showed the charred wreckage of an overturned big rig and a gray SUV with extensive front end damage.
Remarkably, police say no one was injured in the crash.
All lanes of I-295 were shut down in the area for about two hours as crews worked to clear the scene.
There is still no word what caused the accident.