It happened around 5:55 Saturday morning on the 2000 block of Cecil B. Moore Avenue near Woodstock Street.
Police tell Action News that they received a 911 call reporting that a person was shot.
Arriving officers found an off-duty police officer lying in the street suffering from multiple gunshot wounds to the body.
He was taken to Hahnemann Hospital where he was later pronounced dead.
Police are currently on the 2000 block of Cecil B. Moore with K-9 dogs searching for a possible suspect.
So far no word what sparked the shooting.
Stay with Action News and 6abc.com as this story develops.