It was around 3:15 a.m. when the victim, a 24-year-old woman, was walking in the area of Griscom and Church streets when she was attacked.
Police say the man beat the victim in the face and head then sexually assaulted her.
The woman was rushed to the hospital in serious condition.
Anyone with information is asked to contact Philadelphia Police at 215.686.TIPS (8477), text a tip to PPD TIP (773847) or through phillypolice.com.