The 2003 U.S. Open champion and former No. 1 announced his plans to retire at a news conference Thursday, his 30th birthday.
The 20th-seeded Roddick is scheduled to play Bernard Tomic in the second round Friday night at Arthur Ashe Stadium.
The American's surprising decision to walk away from the sport comes a day after four-time major champion Kim Clijsters played the last singles match of her career, a second-round loss to Laura Robson at Flushing Meadows.
