The burglary happened at the Tag clothing store in the 4300 block of Main Street.
Investigators say it was around 2:10 a.m. Wednesday when two unknown men broke out a window and stole 100 pairs of women's jeans, sold for $200 each, 10 women's shirts sold at $92 each and 10 men's shirts sold at $88 each.
Police say the total reported loss to the store, including damage and the stolen merchandise, was more than $30,000.
Investigators say the two male suspects may have fled in a White Chevy Impala with tinted windows.
Anyone with information is asked to contact Philadelphia Police at 215.686.TIPS (8477), text a tip to PPD TIP (773847) or through phillypolice.com.