Police say Struthers was arrested early Wednesday morning after being pulled over on U.S. Route 1 in the southern Maine resort town of Ogunquit. She was charged with criminal operating under the influence and posted $160 bail.
The 65-year-old actress has been performing at the Ogunquit Playhouse in the musical "9 to 5."
The Associated Press left messages at the playhouse and with her publicist. Police had no information on whether she had an attorney.
Struthers is best known for her role as Gloria Stivic in the 1970s TV sitcom "All in the Family" and later for heart-tugging ads seeking money for children's charities.