Kolb was sharp, hitting 17 of 24 passes, and Arizona (3-0) sacked Vick five times for its best start since 1974, more than a dozen years before the team moved to the desert. The Cardinals also have won seven straight home games, the second-longest streak in franchise history.
Philadelphia (2-1) became the first NFL team to open a season with two one-point wins. The Eagles didn't give themselves a chance to rally for another victory, picked apart by the quarterback they cast away and hounded by Arizona's attacking defense.
The NFL's best offense the first two games, the Eagles had three turnovers, running their season total to 12.