It happened at 2:30 p.m. on the ramp leading from the turnpike to the King of Prussia toll plaza.
Images from Chopper 6 HD showed a White Glove Moving and Storage truck lying on its side on the curved off-ramp.
Pennsylvania State Police tell Action News four people were in the truck when it overturned.
All were taken to Paoli Memorial Hospital with non-life-threatening injuries.
It took crews about an hour to clear the scene and reopen the ramp.