The crash happened in the in the area of mile marker 46 in Lower Makefield.
Police say the driver of a Honda Civic travelling southbound lost control, going across the median and hitting a Honda Accord going northbound.
Rescuers arrived to find both vehicles blocking both lanes of travel on Interstate 95.
The drivers were taken to the hospital with unspecified injuries.
An investigation into this crash continues.
Anyone with information is asked to call Pennsylvania State Police at Trevose at 215-942-3900.
