The movie studio is replacing Enrico, a former CEO of PepsiCo Inc. who had served as chairman since DreamWorks went public in 2004, with board member Mellody Hobson.
Dreamworks did not give a reason for Enrico's resignation in its release Thursday.
The company makes a few big-budget animated movies every year, including "Kung Fu Panda" and "Madagascar," along with some TV specials. It signed a five-year distribution deal with News Corp.'s 20th Century Fox in August.
Shares of DreamWorks Animation SKG Inc. are up 8 cents to $20.59 in afternoon trading.