Officers tell Action News that the accident at 10th Street and Oregon Avenue happened shortly after 8:30 p.m. Sunday.
The bicyclist, a 52-year-old man died at the Hospital of the University of Pennsylvania about an hour after the accident. The motorcyclist, a 28-year-old man also died at the hospital.
No names have been released by authorities.
Investigators kept the intersection closed for several hours while they sifted through evidence about the deadly accident.