Police and medics were called out to the 100 block of Garnet Street shortly before 1:00 a.m. Sunday where several people were gathered on a deck of a home there.
New Castle County police say a car drove up with several men and began a fight. During that altercation one of the men on the deck was stabbed once in the chest.
The 25-year-old victim was taken by ambulance to Christiana Hospital with life threatening injuries.
The suspect fled from the scene. Police are continuing to investigate.