The flames broke out around 6:00 Saturday night on the 700 block of South 4th Street and spread to several row homes.
Heavy smoke filled the area and could be seen from miles away.
Philadelphia firefighters had to rescue one of their own who was trapped in the debris.
Firefighters stood side by side and saluted the captain from Ladder 27 who was killed after a roof and wall collapsed.
The fire roared out of control for hours from the three story building on the stretch known as "Fabric Row."
Neighbors say the fire started in the basement of a business called Jack B Fabrics and spread to other parts of the business and apartments upstairs.
Another firefighter suffered burns while trying to save his fallen captain. He was treated at a local hospital and is expected to survive.
The fire forced several residential evacuations and sent several blocks into darkness.
PECO reported more than 300 customers were without power as firefighters worked to contain the blaze.
The Red Cross is assisting at least 17 people. Anyone affected can go to the Nebinger School at 6th and Carpenter streets for assistance.
Nearly a year ago, Philadelphia firefighters mourned the loss of Lt. Robert Neary and Firefighter Daniel Sweeney, who were killed battled a 5-alarm warehouse fire in Kensington.
