The accident happened just before 11:30 p.m. on the southbound lanes of Route 73 in the township's Cedarbrook section.
Police say a vehicle traveling north on Route 73 left the highway and struck a tree, bursting into flames.
The male driver was ejected from the vehicle upon impact.
Responding police officer found the vehicle fully engulfed in flames and pulled the unconscious driver away to safety.
Fire crews responded and upon extinguishing the flames, a deceased female passenger was discovered inside the vehicle.
The driver was taken to Cooper University Hospital in critical condition.
The identities of the victims are not known at this time.
The crash is under investigation.