The shooting occurred in the 600 block of West 4th Street Saturday at approximately 8:30 p.m.
Upon arrival, officers located the 26-year-old victim suffering from a gunshot wound to his head.
The victim was transported to Christiana Hospital by ambulance where he later died.
At this time, detectives do not have a suspect or motive.
Anyone with information should call Detective Brian Conkey at 302-576-3660.