The crash occurred just before 12:30 p.m. on Route 13 northbound just north of the Route 13 and Route 40 split.
The crash involved a 2008 Ford van, a 2006 Volvo tractor trailer, and a 2003 Volvo passenger vehicle.
According to police, the Volvo passenger vehicle was attempting to make a left turn toward the EconoLodge when the car struck the Ford van and the Volvo tractor trailer.
Police say the 27-year-old male driver of the Volvo passenger vehicle was trapped briefly and was transported to Christiana Hospital suffering from a head injury.
No other injuries were reported.