The incident occurred just before 10:00 p.m. along the100 block of Tiber Street.
Officers were chasing down a man suspected of being involved in drugs when they stumbled upon the marijuana in the backyard of a home.
They say the garden had plants that were 6 feet tall and a street value of more than $10,000.
Two adults were taken into custody and police are awaiting a search warrant as they continue to investigate.