The shooting happened at 12:30 p.m. in the first block of Butler Street.
Police say the incident began with an altercation on Hamilton Avenue.
The victim was chased by two suspects several blocks before being gunned down in front of Italian People's Bakery.
There have been no arrests in this case. The name of the victim has not been released.
This is Trenton's 32nd homicide of the year. The previous record of 31 homicides was set back in 2005.