The accident happened just after 6:00 a.m. Friday between Exits 41 and 38 in Winslow Township.
Chopper 6 was over the scene shortly after the accident occurred where two of the four vehicles involved remained on the highway, heavily damaged. In addition, a pickup truck could be seen far into the grassy median of the highway.
Police say a Toyota sedan rear ended a dump truck and flipped over, while on its roof the the Toyota was struck again by a Ford F-250 truck and again by a Honda Accord.
The driver of the Toyota that flipped and a person inside the Honda were flown to Cooper Hospital in Camden in serious condition.
An additional person inside the Honda was transported to Cooper via ambulance, also in serious condition.
Two people, the driver of the Ford F-250 and the dump truck, had minor injuries and refused treatment.
The cause for the accident remains under investigation.