The accident happened around 11:30 p.m. at the intersection of Front Street and Hunting Park.
Police say the driver of a passenger car suffered face and leg injuries after his vehicle rear-ended the bus.
The victim was rushed to Temple University Hospital in critical condition.
The 48-year-old driver of the SEPTA bus treated for a back injury and released from the hospital.
There were ten people onboard the bus at the time. None were seriously injured.
The crash is under investigation.
