It happened at 4:37 a.m. Monday on Route 322 near Route 295.
Police say a 2010 Ford Explorer travelling westbound left the roadway and struck a guardrail and state highway sign, as well as a light standard.
The SUV then crossed over the two westbound lanes, the center median and the two eastbound lanes before coming to rest.
A 48-year-old man sustained serious injuries in the accident. He was rushed to the hospital where he later died.
The victim's identity has not been released.
The cause of the crash remains under investigation.