The fire was reported around 11:30 a.m. in the 5900 block of Vera Cruz Road in Upper Milford Township.
The township manager told Action News that the fire is burning at the Seedway company, which is a seed processing facility.
Chopper 6 HD first showed the massive plume of smoke while in the air over Montgomery County.
Once on the scene, the view from Chopper 6 showed the flames raging outside the building.
The building itself did not appear to be on fire.
However, it's not yet known exactly what was burning.